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Chloroquine, also known by its CAS number 54-05-7, is a pharmaceutical substance primarily used for its antimalarial properties. It belongs to the class of 4-aminoquinoline compounds and is widely used in the prevention and treatment of malaria, caused by Plasmodium species. This pharmaceutical substance works by interfering with the growth and reproduction of the parasites in the red blood cells. Chloroquine inhibits heme polymerase enzyme, resulting in the accumulation of toxic heme metabolites within the parasites. This accumulation ultimately leads to the death of the parasites, thereby reducing the severity and duration of malarial infections. In addition to its antimalarial effects, chloroquine also exhibits immunomodulatory and anti-inflammatory properties. It has been used to treat certain autoimmune diseases, such as rheumatoid arthritis and lupus erythematosus, by reducing the production and release of pro-inflammatory cytokines. Chloroquine is available in various formulations, including tablets -
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Halofantrine, with CAS number 69756-53-2, is a pharmaceutical substance used for the treatment of malaria. It belongs to the class of antimalarial agents and is primarily used to treat infections caused by Plasmodium falciparum, which is a severe and potentially fatal form of malaria. Halofantrine is available in tablet form and is administered orally. It works by targeting the parasite's ability to reproduce and survive in the body. The substance interferes with the formation of hemozoin, a toxic byproduct of hemoglobin digestion by the parasites, leading to their death. While halofantrine has shown effectiveness in treating malaria, it is recommended to be used cautiously due to its potential side effects. Common side effects may include gastrointestinal discomfort, vomiting, and dizziness. It may also cause cardiac complications, such as QT prolongation, which can lead to abnormal heart rhythms. As with any pharmaceutical substance, it is important to carefully follow the prescribed dosage and duration -
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Hydroxychloroquine, also known by its CAS number 118-42-3, is a pharmaceutical substance primarily used to treat malaria, rheumatoid arthritis, and lupus erythematosus. It belongs to the class of medications known as antimalarials and is derived from the closely related drug chloroquine. Hydroxychloroquine works by interfering with the growth and reproduction of parasites, thereby preventing the spread of malaria within the body. Additionally, it exhibits immunomodulatory properties that help control autoimmune diseases like rheumatoid arthritis and lupus erythematosus. This pharmaceutical substance is available in oral tablet or suspension form, providing a safe and effective treatment option for various medical conditions. -
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Product: Artesunate CAS Number: 88495-63-0 Artesunate is a pharmaceutical substance used in the treatment of malaria, specifically for the treatment of severe cases or cases resistant to other antimalarial drugs. It belongs to the class of artemisinin derivatives, which are derived from the Chinese herb Artemisia annua. Artesunate exhibits potent antimalarial activity by specifically targeting the Plasmodium parasite responsible for causing malaria. It works by interfering with the parasite's ability to reproduce and spread, ultimately leading to its death. This mechanism of action makes it effective against both the blood stage and the dormant liver stage of the parasite. As a pharmaceutical substance, artesunate is typically administered through injection or oral tablets. It is rapidly absorbed and converted into its active form, dihydroartemisinin, in the body. The substance has a relatively short half-life, necessitating multiple dosages to ensure adequate therapeutic levels. -
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Artemotil (CAS - 75887-54 beta-arteether) is an antimalarial artemisinin derivative, approved for the treatment of severe cases of P. falciparum malaria. The mixture of artemotil and alpha-arteether is used in patients with cerebral malaria. Most of the artemisinin compounds including artemotil are metabolized into dihydroartemisinin, which is responsible for antimalarial activity. These compounds contain stable endoperoxide bridge. The antimalarial activity of the drug thus is dependent on the cleavage of the endoperoxide by intraparasitic heme. The cleaved endoperoxide ultimately becomes a carbon centered free radical, which then functions as an alkylating agent, reacting with both heme and parasitic proteins (but not DNA). In P. falciparum, one of the principal alkylation target is the translationally controlled tumor protein (DHA-TCTP) homolog. Some intraparasitic TCTP is situated in the membrane surrounding the heme-rich food vacuole, where heme could catalyse the formation of drug-protein (DHA-TCTP) -
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Arterolane, also known as OZ277, is a pharmaceutical substance that is used in the treatment of malaria. Its CAS number is 664338-39-0. Arterolane belongs to the class of antimalarial drugs known as arylaminoalcohols. It works by inhibiting the growth and replication of the Plasmodium parasite responsible for causing malaria. Arterolane is highly effective against both drug-sensitive and drug-resistant strains of Plasmodium falciparum, the most deadly species of malaria parasite. It is commonly used in combination therapy with another antimalarial drug called piperaquine to improve treatment outcomes and prevent the development of drug resistance. Arterolane has a relatively short half-life in the body, allowing for once-daily dosing. It is generally well-tolerated, with mild and transient side effects such as headache, nausea, and dizziness being reported. As an important tool in the fight against malaria, arterolane demonstrates promising results in clinical trials and is being utilized in various malar -
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Pyronaridine, also known as pyronaridine tetraphosphate or as the pharmaceutical substance "Pyronaridine," is a synthetic antimalarial drug that is used for the treatment and prevention of malaria caused by Plasmodium falciparum and Plasmodium vivax. It is classified as a member of the antimalarial class of drugs. The Chemical Abstracts Service (CAS) number for pyronaridine is 74847-35-1. It is formulated as a tetraphosphate salt, which enhances its stability and bioavailability. Pyronaridine works by targeting various stages of the malarial parasite's lifecycle, inhibiting its growth and reproduction within the human body. It has a broad spectrum of activity against multiple drug-resistant strains of malaria and is considered highly efficacious. As a pharmaceutical substance, Pyronaridine is typically available in tablet form for oral administration. It may be used as a monotherapy or in combination with other antimalarial drugs, such as artesunate, to improve efficacy and reduce the risk of drug resistan -
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Product Name: Mefloquine CAS Number: 53230-10-7 Mefloquine is a pharmaceutical substance that belongs to the antimalarial drug class. It is an effective treatment for malaria caused by Plasmodium falciparum and Plasmodium vivax. With a CAS number of 53230-10-7, Mefloquine is known for its ability to prevent and treat malaria, primarily in areas where the disease is resistant to other antimalarial drugs. As a pharmaceutical substance, Mefloquine acts by inhibiting the growth of the malaria parasite within the human body. It disrupts the parasite's ability to replicate and spread, ultimately leading to its destruction. This mechanism of action makes Mefloquine an essential medication for the prevention and treatment of malaria. In addition to its efficacy against malaria, Mefloquine also exhibits some immunosuppressive properties, which may aid in reducing the severity of malaria symptoms. The medication is typically administered orally in tablet form. However, it's important to note that Mefloquine may pro -
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Tafenoquine is a pharmaceutical substance with the name tafenoquine and CAS number 106635-80-7. It is an antimalarial drug used for the prevention and treatment of malaria caused by Plasmodium vivax parasites. Tafenoquine belongs to the class of drugs known as 8-aminoquinolines and works by interfering with the growth and reproduction of the parasites. Tafenoquine is primarily used as a prophylactic treatment for individuals traveling to areas where P. vivax malaria is endemic. It is also used as a radical cure for patients diagnosed with P. vivax malaria to prevent relapse. Tafenoquine is administered orally in tablet form, and its long half-life allows for less frequent dosing compared to other antimalarial drugs. Although tafenoquine has proven to be effective against P. vivax malaria, it may cause some adverse effects. Common side effects include headache, dizziness, nausea, vomiting, and abdominal pain. In rare cases, it can cause hemolytic anemia or severe psychiatric symptoms, such as anxiety and dep -
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Name: Pyrimethamine CAS number: 58-14-0 Pyrimethamine is a pharmaceutical substance that belongs to the class of antiparasitic drugs. It is primarily used in the prevention and treatment of malaria infections caused by Plasmodium falciparum. Pyrimethamine is a white crystalline powder that is odorless and insoluble in water. As a pharmaceutical substance, pyrimethamine acts by inhibiting the enzyme dihydrofolate reductase, which is essential for the synthesis of pyrimidine, a building block of DNA in parasites like Plasmodium. By interfering with this enzyme, pyrimethamine disrupts the production of DNA and RNA, ultimately leading to the death of the parasite. Pyrimethamine is usually administered orally in tablet form or as an injectable solution. The dosage and duration of treatment may vary depending on the severity of the infection and the patient's age and weight. It is often prescribed in combination with other antimalarial drugs, such as sulfadoxine, to enhance its effectiveness and prevent the deve -
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Lumefantrine, with CAS number 82186-77-4, is a pharmaceutical substance used primarily in the treatment of malaria. It is a synthetic antimalarial agent that belongs to the artemisinin-based combination therapy (ACT) class of drugs. Lumefantrine is commonly combined with another antimalarial drug called artemether to form a highly effective treatment for uncomplicated malaria caused by Plasmodium falciparum. Lumefantrine works by inhibiting the growth and replication of the malaria parasite within the red blood cells. It targets the parasite's mitochondrial electron transport chain, leading to disruption of its energy metabolism and ultimately causing its death. The drug is administered orally in tablet form and is generally well-tolerated, with a favorable safety profile. Due to the emergence of artemisinin resistance in some regions, lumefantrine has become an essential component in the fight against malaria. The combination therapy of lumefantrine and artemether has proven to be highly effective, providi -
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Sulfalene is a pharmaceutical substance with the chemical name N-(4-aminophenyl)benzenesulfonamide. It is also known by its CAS number, which is 152-47-6. Sulfalene belongs to the class of sulfonamide antibiotics and is used for the treatment of various bacterial infections. It works by inhibiting the growth and reproduction of bacteria by interfering with their metabolic processes. As a sulfonamide, sulfalene acts by inhibiting the synthesis of folic acid, which is essential for the growth and survival of bacteria. By interfering with folic acid synthesis, sulfalene effectively stops the bacteria from multiplying and spreading. Sulfalene is mainly prescribed for the treatment of urinary tract infections caused by susceptible bacteria. It may also be used to treat other types of infections, such as respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted infections. It is available in various dosage forms, including tablets and suspension, and is typically administer -
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Proguanil, also known by its CAS number 500-92-5, is a pharmaceutical substance used for the prevention and treatment of malaria. It is a derivative of the antimalarial drug atovaquone. Proguanil functions as a prodrug, meaning it is metabolized in the body to its active form, cycloguanil, which inhibits the parasite's ability to synthesize nucleic acids. This disruption ultimately leads to the death of the malaria parasite. Proguanil is available in various formulations, including tablets, which are commonly used for prophylaxis, and combination products with atovaquone for treatment. It is considered an essential medication for the prevention and management of malaria in many regions of the world. -
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Primaquine is a pharmaceutical substance commonly used in the treatment and prevention of malaria. Its chemical name is 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline. The CAS number for primaquine is 90-34-6. This medication belongs to the class of 8-aminoquinolines and is known for its efficacy against Plasmodium parasites, the causative agents of malaria. Primaquine works by interfering with the DNA and RNA synthesis of the parasite, thereby inhibiting its ability to reproduce and spread throughout the body. It is often used in combination with other antimalarial drugs to provide a comprehensive approach to the treatment and prevention of malaria. -
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Amodiaquine, also known by its CAS number 86-42-0, is a pharmaceutical substance used for the treatment of malaria. It belongs to the class of antimalarial drugs and is commonly used in combination with other medications to increase its effectiveness. Amodiaquine works by interfering with the growth and replication of the malaria parasite, thus helping to eliminate the infection from the body. It is available in various forms such as tablets, capsules, and syrups for oral administration. Amodiaquine is a crucial component in the global efforts to combat malaria, particularly in regions where the disease is prevalent. -
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Cycloguanil pamoate is a pharmaceutical substance that belongs to the class of antimalarial drugs. Its chemical name is 4,6-diamino-N-(2,5-dimethoxyphenyl)-1,3,5-triazin-2-amine pamoate. The CAS number of Cycloguanil pamoate is 609-78-9. Cycloguanil pamoate is used in the treatment and prevention of malaria caused by Plasmodium falciparum, a parasite transmitted through the bite of infected mosquitoes. It works by inhibiting the replication of the parasite, ultimately reducing the symptoms and preventing further transmission of the disease. This pharmaceutical substance is typically administered orally or intravenously. Common side effects may include nausea, vomiting, diarrhea, headache, and dizziness. It is important to follow the prescribed dosage and complete the entire course of treatment to ensure effectiveness. Overall, Cycloguanil pamoate is an essential component in the fight against malaria, a life-threatening disease that impacts millions of people worldwide. -
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Artenimol, also known as dihydroartemisinin (CAS number: 71939-50-9), is a pharmaceutical substance used in the treatment of malaria. It is derived from the Chinese herb Artemisia annua and belongs to the artemisinin class of antimalarial agents. Artenimol acts by rapidly killing the malaria parasites in the blood, making it highly effective in the treatment of both uncomplicated and severe cases of malaria. Its mechanism of action involves the production of reactive oxygen species, which cause oxidative stress and damage to the parasite's cell structures. Artenimol is typically administered in combination with other antimalarial drugs to prevent the development of drug resistance. -
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Name: Quinine CAS Number: 130-95-0 Description: Quinine is a pharmaceutical substance that is derived from the bark of the cinchona tree. It is a white crystalline substance with a bitter taste. Quinine possesses antimalarial properties and is primarily used in the treatment and prevention of malaria. It is known for its ability to kill the malaria parasite in the bloodstream, thereby providing relief from the symptoms of the disease. Quinine works by interfering with the parasite's ability to break down hemoglobin, which is vital for its survival. As a result, the parasite is unable to replicate and infect new red blood cells. In addition to its antimalarial properties, quinine also possesses antipyretic (fever-reducing) and analgesic (pain-relieving) properties. Quinine is available in various forms, including tablets, capsules, oral solutions, and injections. The dosage and administration of quinine depend on the severity of the malaria infection and the patient's age and weight. Although effective ag -
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Quinine sulfate is a pharmaceutical substance used primarily as an antimalarial agent. Its chemical name is (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol sulfate. The CAS number for quinine sulfate is 6119-70-6. Quinine sulfate works by interfering with the growth and reproduction of the malaria parasite, Plasmodium. It is often used in combination with other antimalarial drugs to enhance its effectiveness and prevent the development of resistance. Quinine sulfate can be administered orally or intravenously depending on the severity of the infection. Aside from its antimalarial properties, quinine sulfate also exhibits muscle relaxant properties, which has led to its use in the treatment of muscle cramps and spasms. However, its use in this regard is limited, and other medications are generally preferred due to the potential side effects and toxicity associated with quinine sulfate. Common side effects of quinine sulfate include nausea, headache, dizziness, and ri -
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Artemisinin, with the CAS number 63968-64-9, is a naturally occurring compound derived from the plant Artemisia annua, also known as sweet wormwood or annual wormwood. It is a sesquiterpene lactone with a unique chemical structure and possesses antimalarial properties. Artemisinin has been used for centuries in traditional Chinese medicine as a treatment for fever and malaria. However, its full potential as an effective antimalarial drug was realized in the 1970s by Chinese scientist Tu Youyou, who was awarded the Nobel Prize in Physiology or Medicine in 2015 for her work on artemisinin. This pharmaceutical substance works by interacting with iron and forming reactive oxygen species inside the malaria parasite, leading to its destruction. As a result, artemisinin and its derivatives are considered first-line treatments for uncomplicated malaria, particularly for chloroquine-resistant strains. Artemisinin-based combination therapies (ACTs) are currently recommended by the World Health Organization (WHO) as -
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Product Name: Piperaquine CAS Number: 4085-31-8 Piperaquine is a pharmaceutical substance that belongs to the class of antimalarial agents. It is used in the treatment and prevention of malaria caused by Plasmodium falciparum and Plasmodium vivax. It exhibits potent antimalarial activity and is commonly administered in combination with other antimalarial drugs, such as artemisinin derivatives, to prevent the development of drug resistance. Chemically, piperaquine is known as 1,3-bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane. It has a molecular formula of C29H32Cl2N6 with a molecular weight of 549.51 g/mol. Piperaquine acts by primarily inhibiting the growth and replication of the malaria-causing parasites within the red blood cells. Piperaquine is available in various formulations, including tablets and oral liquid preparations, for convenient administration. The recommended dosage of piperaquine may vary depending on the age, weight, and severity of the malaria infection. However, it is typically ad -
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Artemether, with the Chemical Abstract Service (CAS) number 71963-77-4, is a pharmaceutical substance used primarily in the treatment of malaria. It is a synthetic derivative of artemisinin, a compound derived from the Chinese herb Artemisia annua. Artemether is classified as an antimalarial agent and belongs to the class of artemisinin-based combination therapies (ACTs). Artemether is available in various pharmaceutical forms, including oral tablets and injection formulations. It is rapidly absorbed and converted into its active metabolite dihydroartemisinin in the body. This metabolite works by interacting with the heme moiety of hemoglobin, leading to the generation of toxic free radicals within malaria parasites, ultimately resulting in their destruction. As a highly effective antimalarial, artemether is recommended for uncomplicated malaria caused by Plasmodium falciparum. It is often used in combination with other antimalarial drugs, such as lumefantrine, to maximize efficacy and reduce the risk of re -
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Propyphenazone, also known as phenazon, is a pharmaceutical substance commonly used as an analgesic and antipyretic medication. Its CAS number is 479-92-5. It belongs to the class of pyrazolone derivatives and is often used to relieve pain associated with headaches, dental pain, and musculoskeletal conditions. Additionally, it can help reduce fever by acting on the hypothalamus, which controls body temperature. Propyphenazone works by inhibiting the synthesis of prostaglandins, which are chemical mediators involved in the transmission of pain signals and the regulation of body temperature. By reducing the production of these inflammatory substances, it helps alleviate pain and fever. This pharmaceutical substance is available in various forms, including tablets, capsules, and injections, and is often used in combination with other analgesics and antipyretics. It is typically administered orally, but injections may be used in severe cases. Although propyphenazone is generally considered safe when used as d -
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CRISABOROLE is a pharmaceutical substance with the CAS number 906673-24-3. It is an ointment that is used topically for the treatment of mild-to-moderate atopic dermatitis (eczema) in patients aged 2 years and older. CRISABOROLE belongs to a class of medications called phosphodiesterase 4 (PDE4) inhibitors. It works by inhibiting the enzyme PDE4, which reduces inflammation and itching associated with atopic dermatitis. This drug is believed to have both anti-inflammatory and anti-itch properties. The ointment is typically applied directly to the affected skin twice daily. It is important to follow the instructions provided by a healthcare professional and to avoid using this medication on broken or infected skin. Common side effects of CRISABOROLE may include burning or stinging sensation at the application site, as well as skin redness or irritation. As with any medication, it is important to consult a healthcare professional before using CRISABOROLE to determine if it is suitable for individual circumsta
